High-value cards such as aces, kings, queens, and jacks help form sets, while low-value cards help form runs. It is also important to look for cards that have multiple uses. Doing so will give you morreal cash game rummye flexibility and options as the game progresses. Forming Sets & Runs When developing an opening hand strategy, it is important to consider the potential combinations of cards in your hand and how they can be used to form sets and runs. For example, if there are several cards of the same rank or a sequence of cards of the same suit, it is likely that a set or run can be formed early in the game.